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      DISEASE MOUSE MODELS

      Model animals, as an important tool for human disease research, aid in the investigation of disease mechanisms and the development of therapies. Mouse models, being the most extensively used model animals, are employed in a variety of areas, such as fundamental scientific research, drug discovery, preclinical evaluation, and clinical technology development. Mice have a close relationship with humans, advanced genetic manipulation, fast reproduction, and a clear genetic background. Gene editing technology can provide suitable disease models for study based on disease-related genes. GemPharmatech has produced numerous disease models using gene editing technologies, such as spontaneous tumor models, obesity models, diabetes models, Alzheimer's disease models, Parkinson's disease models, and so on. Through phenotypic analysis, GemPharmatech has also confirmed the incidence and development of numerous model-related phenotypes, providing solid support for the research of various diseases.

      Introducing GemPharmatech's Latest Strains: Unveiling the Future of Innovation


      Strain ID

      Strain Name

      Application

      T055223


      B6-Tg(hSOD1 G93A,hSOD1) 圖片1.png

      Genetic humanization, ALS disease

      T058996

      FAD4T-hTREM2 圖片1.png

      Genetic humanization, Alzheimer's disease

      T054322

      B6-hSNCA E46K A53T

      Genetic humanization, Parkinson's disease

      T056757

      B6-hCD36

      Genetic humanization, neuroinflammation

      T056002

      B6-Dmd Del45

      Duchenne muscular dystrophy, 45 exon deletion

      T055631

      B6-hDLL4

      Genetic humanization, oncology

      T056429

      B6-hCD34

      Genetic humanization, oncology

      T058753

      B6-hCEACAM5-Tg

      Genetic humanization, oncology

      T053316

      B6-hIL18R1/hIL18RAP

      Genetic humanization, oncology

      T037007

      B6-hCD47/hSIRPA 圖片1.png

      Genetic humanization, oncology

      T056010

      BALB/c-hCD44

      Genetic humanization, oncology

      T054198

      BALB/c-hGPC3

      Genetic humanization, oncology

      T054490

      BALB/c-hSEMA4D

      Genetic humanization, oncology

      T054543

      BALB/c-hHSA

      Genetic humanization, oncology

      T056432

      BALB/c-hTROP2 圖片1.png

      Genetic humanization, oncology

      T056011

      BALB/c-hCD44v6

      Genetic humanization, oncology

      T055714

      BALB/c-hCS1

      Genetic humanization, oncology

      T056083

      BALB/c-hLRRC15

      Genetic humanization, oncology

      T056430

      BALB/c-hNECTIN-4

      Genetic humanization, oncology

      T058266

      BALB/c-hTIGIT/hPVRIG

      Genetic humanization, oncology

      T054842

      BALB/c-hPD1/hPDL1/hTIGIT/hCD9 圖片1.png

      Genetic humanization, oncology

      T058749

      BALB/c-hPD1/hPDL1/hCD73/hCD39 圖片1.png

      Genetic humanization, oncology

      T009819


      BALB/c-hHER2 圖片1.png


      Genetic humanization, oncology

      T009813

      NCG-hHER2

      Genetic humanization, oncology

      T054081

      NOD-Scid-hNKp30

      Genetic humanization, oncology

      T056195

      B6-hIGHA1

      Genetic humanization, autoimmune disease


      T054583

      BALB/c-hIL1RL1

      Genetic humanization, autoimmune disease

      T054645

      BALB/c-hKLRB1

      Genetic humanization, autoimmune disease

      T003277

      BALB/c-hIL17A 圖片1.png

      Genetic humanization, autoimmune disease

      T053555

      BALB/c-hIL1β

      Genetic humanization, autoimmune disease

      T054186

      BALB/c-hTLR8

      Genetic humanization, autoimmune disease

      T055268

      BALB/c-hFcgRs/hCD47/hSIRPA 圖片1.png

      Genetic humanization, Fc end modification for antibody drugs, ADCC effect

      T058940

      BALB/c-hCD3EDG/hCD22

      Genetic humanization, CD3 bispecific antibody related

      T057420

      BALB/c-hCD73/hCD3EDG 

      Genetic humanization, CD3 bispecific antibody related

      T058817

      BALB/c-hGPRC5D/hCD3EDG 圖片1.png

      Genetic humanization, CD3 bispecific antibody related

      T059045

      BALB/c-hCD3EDG/hBCMA 圖片1.png

      Genetic humanization, CD3 bispecific antibody related

      T058351

      B6-Rosa26-hAGT 圖片1.png

      Genetic humanization, hypertension

      T058352

      B6-H11-hREN

      Genetic humanization, hypertension

      T054639

      B6-hCD200R1

      Genetic humanization, atherosclerosis research

      T058217

      B6-hAPOB-Tg

      Genetic humanization, hypercholesteremia and atherogenesis

      T058211

      B6-hAPOE-DGAT2-LE1 圖片1.png

      Genetic humanization, NASH

      T051403

      B6-Myh6-R404Q 圖片1.png

      Hypertrophic cardiomyopathy

      T027708

      B6-Mybpc3-KO

      hypertrophic cardiomyopathy or dilated cardiomyopathy

      T007085

      B6-Kras-G12D/wt; Lyz2-iCre

      Spontaneous lung cancer

      T053603

      kras-G12C 圖片1.png

      Kras-related spontaneous tumors

      T057165

      KPS 圖片1.png

      Spontaneous lung cancer

      T057162

      KS

      Spontaneous lung cancer


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